DOM FIGURE 1 Effect of single exposure to AZD1656 or PF-04991532 on blood glucose and insulin and liver gene expression.
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Male C57BL/6 mice were treated with vehicle or AZD1656 (A,E) at the doses indicated 2h before an oral glucose tolerance test or with PF-04991532 (B,F) 1h before the oral glucose tolerance test. C,G. Changes in blood glucose (C) and insulin (G) after treatment with AZD1656 or PF-04991532 before glucose gavage. D. Blood glucose, area under the curve. H. Plasma insulin, area under the curve. I. Liver mRNA levels for the indicated genes normalized to TATA-Binding Protein (TBP) and to vehicle controls. Means ± SEM, n=8, * P < 0.05 relative to vehicle, except for C,G relative to time zero.
MICA: Exploring a new perspective on the mechanism of action of Glucokinase Activators in liver, a preclinical study
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