BP Figure-8: Insulin tolerance test inGckr^del/wtandGckr:P446L studies

A) Gckr^del/wt study: body weight and insulin tolerance test, blood glucose after insulin challenge and area under the curve (AUC) performed after 12-wk of HFD -/+ AZD1656 (3 mg/kg body wt) in mice aged 30 wk. B) Gckr:P446L study: body weight and insulin tolerance test performed after 12 wk of HFHSD -/+ AZD1656 (3 mg/kg body wt) in mice were aged 20 wk. * P < 0.05 effect of AZD1656.