Newcastle University
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Votucalis data_Frontiers in Pharmacology_2022

posted on 2022-02-23, 10:33 authored by Ilona ObaraIlona Obara, Ibrahim Alrashdi, Amal Alsubayiel, Michele Chan, Abdel Ennaceur, Paul Chazot

This data underlay findings included in "Votucalis, a Novel Centrally Sparing Histamine-binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice" accepted for publication in Frontiers in Pharmacology.

The study explored novel refractory therapeutic indications based on scavenging of peripherally released endogenous histamine by Votucalis and focused on mouse models of acute itch and chronic neuropathic pain. Our overall findings further emphasise the key role for histamine in the regulation of histaminergic itch and chronic neuropathic pain.


Funded by a PhD scholarship from the Saudi Arabian government to Ibrahim Alrashdi and partially funded by Akari Therapeutics Plc and the Medical Research Council Confidence in Concept scheme to Paul L Chazot and Ilona Obara (MC/PC/17157).



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