DATASET
Itch_Votucalis_ChloroQ.csv (3.56 kB)
DATASET
Itch_Votucalis_Compound4880.csv (7.75 kB)
DATASET
Itch_Votucalis_JNJ.csv (2.43 kB)
DATASET
Itch_Votucalis_Mepyramine.csv (3.14 kB)
DATASET
Itch_Votucalis_Ranitidine.csv (2.05 kB)
DATASET
Neuropathic_Votucalis_Hargreaves.csv (20.49 kB)
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Neuropathic_Votucalis_Von Frey.csv (21.17 kB)
DATASET
Spontaneous object recognition_Votucalis.csv (2.05 kB)
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Votucalis data_Frontiers in Pharmacology_2022
dataset
posted on 2022-02-23, 10:33 authored by Ilona ObaraIlona Obara, Ibrahim Alrashdi, Amal Alsubayiel, Michele Chan, Abdel Ennaceur, Paul ChazotThis data underlay findings included in "Votucalis, a Novel Centrally Sparing Histamine-binding Protein, Attenuates Histaminergic Itch and Neuropathic Pain in Mice" accepted for publication in Frontiers in Pharmacology.
The study explored novel refractory therapeutic indications based on scavenging of peripherally released endogenous histamine by Votucalis and focused on mouse models of acute itch and chronic neuropathic pain. Our overall findings further emphasise the key role for histamine in the regulation of histaminergic itch and chronic neuropathic pain.
Funding
Funded by a PhD scholarship from the Saudi Arabian government to Ibrahim Alrashdi and partially funded by Akari Therapeutics Plc and the Medical Research Council Confidence in Concept scheme to Paul L Chazot and Ilona Obara (MC/PC/17157).
History
UoA
- Allied Health Professions, Dentistry, Nursing and Pharmacy
