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Targeted RNA Sequencing of a panel of ovarian cancer cell lines
datasetposted on 19.03.2021, 13:39 by Alice Bradbury,, Yvette Drew, Nicola Curtin, Sweta Sharma Saha
Assess the baseline expression of the genes in the Oncology Biomarker Panel across the panel of ovarian and cervical cancer cell lines. This data will then be compared to the sensitivity of the cell lines to DDR inhibitors. The expression data will be correlated with the sensitivity of the cell lines to see whether determinants of sensitivity described in the literature translate. A hierarchy of genes will be determined. It is expected that the cells that are more sensitive to DDR inhibitors will have decreased expression of the genes known to be determinants of sensitivity.