MolMet Figure 8: Correlation of liver transcripts with phenotypic traits in the P446L mouse on the HFHSD.

<p>A) Correlation of phenotypic traits with corresponding gene counts from the liver transcriptome for the P446L mouse (PP,LL, n=9/10) on the HSFSD showing:</p> <p>(i) Blood glucose (BG) and blood insulin (BI) correlated negatively with genes induced by GK excess (<em>Scl2a2</em>, <em>Slc25a47</em>, <em>Rgs16</em>, <em>G6pc</em>, <em>Rorc</em>) in the hepatocyte transcriptome (Figure 2).</p> <p>(ii) Blood glucose and insulin correlated positively with <em>Hmgcr</em> and other genes linked to cholesterol biosynthesis (<em>Msmo1</em>, <em>Insig2</em>, <em>Cyp51a1</em>) and negatively with genes linked to cholesterol excretion (<em>Abcg5</em>, <em>Abcg8</em>).</p> <p>(iii) Inorganic phosphate (Pi) correlated negatively with <em>G6pc</em>;</p> <p>(iv) Blood cholesterol (TC, HDL, LDL) correlated positively with <em>Slc25a47</em> and <em>Slc25a10</em> and negatively with <em>Tm7sf2</em>).</p>