MolMet Figure 4: Blood metabolites and liver transcriptome in the P446L mouse on regular diet.

<p>A) Male mice aged 14 wk: body weight, free-feeding blood glucose, plasma insulin and plasma triglyceride; n=6-9. B) Female mice aged 14 wk: body weight; plasma triglycerides; liver triglycerides, n=15-17 and glucose tolerance, n=7,7.</p> <p>C) Heat map of differentially expressed genes (DEGs, padjust < 0.05) in livers of male mice by LL genotype and the direction of the log fold change (LFC) of expression values.</p> <p>D) Top pathways from the Ingenuity Pathway Analysis showing corresponding P value and Z scores.</p> <p>E) Venn diagram showing numbers of common genes that are significantly differentially expressed (upregulation, red; down-regulation green) in male mice by LL genotype and are differentially expressed in female PP vs male PP mice.</p> <p>F) Gene counts for P446L male and female mice for common genes from E).</p> <p>G) Box plot of gene counts from RNA-sequencing for 12 <em>Mup</em> genes showing lower expression in male LL mice and in female PP and LL mice; n=4,4,5,5,(M-P, M-L, F-P, F-L).</p>