Data for pulsatile release from chitosan hydrogel
datasetposted on 01.01.2018 by A Isakova, K Novakovic
Datasets usually provide raw data for analysis. This raw data often comes in spreadsheet form, but can be any collection of data, on which analysis can be performed.
Coupling oscillatory chemical reactions to smart materials which can respond to external stimuli is considered an answer to the long-standing issue of pulsatile drug delivery. Although a number of coupled architectures exist, there are no systems reporting pH-controlled pulsed drug release based on chemical oscillators. In this paper, we report for the first time a proof-of-concept self-oscillatory chitosan macrogel, employing the palladium-catalysed oxidative carbonylation reaction as the driving force of its oscillations. The reported hydrogel is composed of highly biocompatible components and a novel imine-functionalised chitosan-palladium catalyst with zero leaching rates. This macrogel was shown to rhythmically release not only the products of the reaction, but also fluorescein, which is used as an FDA-approved model drug. The step-wise release pattern corresponded to the step-wise dynamics of pH decrease in methanol:water, while in pure methanol, the changes in pH had an oscillatory mode, accompanied by mirrored oscillations in fluorescein concentration. This proof-of-concept system significantly expands the horizons of pulsatile delivery materials for future research.