Experimental details were as in Fig. 3(E-L). C57BL/6 mice were treated with AZD1656 (1 mg/kg or 3 mg/kg body weight) for either 4 weeks or 8 weeks (n=6 per group culled for liver analysis). Immunoactivity to GKRP, G6Pase and Gpd2 is expressed relative to β-actin.
Funding
MICA: Exploring a new perspective on the mechanism of action of Glucokinase Activators in liver, a preclinical study