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Figure1.pzfx (77.97 kB)

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Figure 1 A B C Glucose.xlsx (15.34 kB)

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Figure 1 C G Insulin stats.xlsx (10.95 kB)

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Figure 1 D AUC Stats.xlsx (37.55 kB)

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Figure 1 D AUC.pzfx (197.1 kB)

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Figure 1 E F Insulin GTT.xlsx (2.04 MB)

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Figure 1 H Insulin AUC.pzfx (210.25 kB)

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Figure 1 I 1-wk Liver GE.xlsx (281.86 kB)

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DOM FIGURE 1 Effect of single exposure to AZD1656 or PF-04991532 on blood glucose and insulin and liver gene expression.

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posted on 2020-06-25, 09:36 authored by Brian FordBrian Ford, Loranne AgiusLoranne Agius

Male C57BL/6 mice were treated with vehicle or AZD1656 (A,E) at the doses indicated 2h before an oral glucose tolerance test or with PF-04991532 (B,F) 1h before the oral glucose tolerance test. C,G. Changes in blood glucose (C) and insulin (G) after treatment with AZD1656 or PF-04991532 before glucose gavage. D. Blood glucose, area under the curve. H. Plasma insulin, area under the curve. I. Liver mRNA levels for the indicated genes normalized to TATA-Binding Protein (TBP) and to vehicle controls. Means ± SEM, n=8, * P < 0.05 relative to vehicle, except for C,G relative to time zero.